James Dowling Trask *
نویسندگان
چکیده
منابع مشابه
Cutaneous Infectivity in Experimental Poliomyelitis
1. Bilateral olfactory neurectomy did not prevent experimental poliomyelitis on intravenous or intracutaneous inoculation. 2. Various operative procedures increased the susceptibility of monkeys to infection with experimental poliomyelitis.
متن کاملDowling-Degos disease: Report of a case with pigmentation localized only in the genital area
Dowling –Degos disease is a rare condition. It is inherited by an autosomal dominant gene. It usually presents in adult life as small, pigmented, asymptomatic macules in flexural regions. We report a 35-year-old woman with Dowling- Degos disease, in whom the reticular pigmentation confined to the genital area.
متن کاملThe Structural Features of Trask That Mediate Its Anti-Adhesive Functions
Trask/CDCP1 is a transmembrane protein with a large extracellular and small intracellular domains. The intracellular domain (ICD) undergoes tyrosine phosphorylation by Src kinases during anchorage loss and, when phosphorylated, Trask functions to inhibit cell adhesion. The extracellular domain (ECD) undergoes proteolytic cleavage by serine proteases, although the functional significance of this...
متن کاملTrask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells.
The cell surface glycoprotein Trask/CDCP1 is phosphorylated during anchorage loss in epithelial cells in which it inhibits integrin clustering, outside-in signaling, and cell adhesion. Its role in cancer has been difficult to understand, because of the lack of a discernible pattern in its various alterations in cancer cells. To address this issue, we generated mice lacking Trask function. Mamma...
متن کاملAssociation of Dowling-Degos disease and multiple seborrheick-eratosis in a “Christmas tree pattern”
Dowling-Degos disease is a rare sporadic or autosomal dominant pigmentary entity, in which clusters of papules and reticulate macules slowly develop with predominance in flexural regions. This entity is due to mutations in the keratin 5 gene, and is related with other cutaneous disorders. We report the sporadic form of Dowling-Degos disease in an elderly man with multiple seborrheickeratosis ...
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ورودعنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 14 شماره
صفحات -
تاریخ انتشار 1942